/* Biotech calculator layout, using the same theme tokens as mechanical tools. */
.bio-layout{display:grid;grid-template-columns:minmax(0,1fr) 340px;gap:22px;align-items:start}
.bio-card{border:1.5px solid var(--border);border-radius:14px;padding:24px;background:var(--bg);min-width:0}
.bio-card h2{font-size:1.1rem;line-height:1.5;margin:0 0 22px}
.bio-section-label{font-size:.7rem;font-weight:800;text-transform:uppercase;letter-spacing:.085em;color:var(--text-sec);margin-bottom:9px}
.bio-field{margin-bottom:18px;min-width:0}
.bio-field>label{display:block;font-size:.8rem;font-weight:700;margin-bottom:6px}
.bio-field small{display:block;font-size:.73rem;color:var(--text-sec);line-height:1.55;margin-top:5px}
.bio-field input,.bio-field select,.bio-field textarea{min-width:0;width:100%;background:var(--bg);color:var(--text);font:inherit;font-size:.9rem;border:1.5px solid var(--border);border-radius:8px;padding:11px}
.bio-field textarea{font-family:Consolas,monospace;resize:vertical;line-height:1.65}
.bio-field input:focus,.bio-field select:focus,.bio-field textarea:focus{outline:2px solid var(--blue);outline-offset:1px}
.bio-input{display:flex;gap:7px;align-items:center}
.bio-input select{max-width:86px;background:var(--bg-alt)}
.bio-solved input{opacity:.45;background:var(--bg-alt)}
.bio-solved>label:after{content:" · calculated";font-weight:400;color:var(--blue)}
.bio-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));column-gap:16px}
.bio-actions{display:flex;flex-wrap:wrap;gap:9px;align-items:center}
.bio-card button{border:1.5px solid var(--blue);background:var(--blue);color:#fff;border-radius:8px;padding:10px 16px;font:600 .82rem 'Segoe UI',sans-serif;cursor:pointer}
.bio-card button:hover{filter:brightness(.95)}
.bio-card button.secondary{border-color:var(--border);color:var(--text);background:var(--bg)}
.bio-card button:focus-visible,.bio-card summary:focus-visible{outline:3px solid var(--blue);outline-offset:3px}
.bio-result-hero{background:linear-gradient(135deg,var(--blue),var(--blue-dark));color:#fff;border-radius:14px;padding:26px 22px;margin-bottom:18px;overflow-wrap:anywhere}
.bio-result-hero .bio-section-label{color:#fff;opacity:.85}
.bio-result-hero strong{font-size:1.85rem;line-height:1.3;display:block;font-weight:800}
.bio-result-hero p{font-size:.79rem;opacity:.9;margin-top:10px;line-height:1.6}
.bio-formula{font: .78rem/1.65 Consolas,monospace;background:var(--bg-alt);padding:12px;border-radius:8px;overflow-wrap:anywhere}
.bio-method p{font-size:.78rem;color:var(--text-sec);line-height:1.85;margin-top:16px}
.bio-sources{font-size:.75rem;line-height:1.7;margin-top:16px}
.bio-sources a,.bio-related a{color:var(--blue);text-decoration:underline;text-underline-offset:3px}
.bio-results{margin-top:22px}
.bio-result-heading{display:flex;gap:15px;align-items:center;justify-content:space-between;flex-wrap:wrap;margin-bottom:20px}
.bio-result-heading h2{margin:0}
.bio-metrics{display:grid;grid-template-columns:repeat(auto-fit,minmax(170px,1fr));gap:12px;margin:15px 0 20px}
.bio-metrics>div{background:var(--bg-alt);border:1px solid var(--border);padding:16px;border-radius:10px;min-width:0}
.bio-metrics small{display:block;font-size:.73rem;color:var(--text-sec);line-height:1.55}
.bio-metrics strong{display:block;color:var(--blue);font-size:1.15rem;margin-top:7px;overflow-wrap:anywhere}
.bio-table-wrap{overflow:auto;max-height:460px;margin:16px 0;border:1px solid var(--border);border-radius:9px}
.bio-table-wrap table{width:100%;border-collapse:collapse;font-size:.8rem;line-height:1.6}
.bio-table-wrap th,.bio-table-wrap td{padding:11px 14px;text-align:left;border-bottom:1px solid var(--border);vertical-align:top}
.bio-table-wrap th{background:var(--bg-alt);position:sticky;top:0;font-weight:700}
.bio-table-wrap tr:last-child td{border-bottom:0}
.bio-table-wrap td{min-width:70px;overflow-wrap:anywhere}
.bio-results h3{font-size:.95rem;margin:22px 0 12px}
.bio-note{padding:12px 15px;background:var(--blue-light);border-left:3px solid var(--blue);border-radius:6px;font-size:.8rem;line-height:1.7;margin:12px 0;overflow-wrap:anywhere}
#bio-error{margin-top:16px;padding:14px;background:var(--red-bg);color:var(--red);border-radius:8px;font-size:.84rem;line-height:1.6}
.bio-seq-count,#report-status{color:var(--text-sec);font-size:.73rem;margin-top:8px}
.bio-results details{border:1px solid var(--border);border-radius:9px;margin:12px 0;padding:12px}
.bio-results summary{cursor:pointer;font-weight:600;font-size:.83rem}
.bio-results pre{font: .8rem/1.8 Consolas,monospace;white-space:pre-wrap;overflow-wrap:anywhere;word-break:break-all;max-height:300px;overflow:auto;padding:12px;margin-top:10px;background:var(--bg-alt);border-radius:6px}
.bio-enzymes{border:1px solid var(--border);border-radius:9px;padding:14px;display:grid;grid-template-columns:1fr 1fr;gap:12px;margin-bottom:20px}
.bio-enzymes legend{font-size:.8rem;font-weight:700;padding:0 5px}
.bio-enzymes .bio-actions{grid-column:1/-1}
.bio-enzymes>label{display:flex;gap:8px;align-items:flex-start;font-size:.82rem;cursor:pointer}
.bio-enzymes input{width:17px;height:17px;accent-color:var(--blue);margin-top:2px}
.bio-enzymes small{display:block;font: .7rem/1.6 Consolas,monospace;color:var(--text-sec)}
.bio-plot{width:100%;max-height:280px;color:var(--text-sec);margin:18px 0}
.bio-plot text{fill:currentColor;font:11px 'Segoe UI',sans-serif}
.bio-related{margin-top:24px;display:flex;gap:10px 22px;flex-wrap:wrap;font-size:.8rem;line-height:1.7}
.bio-related h2{width:100%;font-size:1rem;margin:0}
[hidden]{display:none!important}
@media(max-width:880px){.bio-layout{grid-template-columns:1fr}.bio-summary{display:grid;grid-template-columns:1fr 1fr;gap:18px}.bio-result-hero{margin:0;align-self:start}.bio-card{padding:20px}}
@media(max-width:560px){.bio-summary,.bio-grid{grid-template-columns:1fr}.bio-card{padding:17px}.bio-metrics{grid-template-columns:1fr 1fr}.bio-metrics>div{padding:12px}.bio-metrics strong{font-size:1rem}.bio-result-heading{align-items:flex-start}.bio-result-hero strong{font-size:1.65rem}.bio-actions button{padding:10px 12px}.bio-enzymes{padding:12px;gap:10px}.tool-hero{align-items:flex-start}.tool-hero-title{font-size:1.35rem}}
@media print{.navbar,.bio-actions,form,.bio-related,footer{display:none}.bio-layout{display:block}.bio-result-hero{color:#000;background:#fff}.bio-result-hero .bio-section-label{color:#000}.bio-table-wrap{max-height:none}.bio-results pre{max-height:none}.bio-card{break-inside:avoid}}